Proton pump inhibitors (PPIs): Cost Comparison
Proton pump inhibitors reduce stomach acid and are used for acid reflux, GERD and ulcers. They are high-volume, low-cost generics in Medicare Part D.
Across these 2 drugs, average Medicare Part D spending per dosage unit ranges from $0.1716 (Omeprazole) to $0.1987 (Pantoprazole Sodium) for calendar year 2024. Figures are real CMS open data, in US dollars.
How much do proton pump inhibitors (ppis) cost in the US?
As of calendar year 2024, average Medicare Part D spending per dosage unit for these 2 proton pump inhibitors (ppis) ranged from $0.1716 (Omeprazole) to $0.1987 (Pantoprazole Sodium), per CMS open data. These are Medicare program spending figures per billing unit — not pharmacy cash prices, and not medical advice.
| Drug | Generic (active ingredient) | Avg Part D spending / dosage unit | 2024 Part D claims |
|---|---|---|---|
| Omeprazole | Omeprazole | $0.1716 | 28,883,231 |
| Pantoprazole Sodium | Pantoprazole Sodium | $0.1987 | 25,600,657 |
Figures are CMS’s own published Medicare Part D spending values (field Avg_Spnd_Per_Dsg_Unt_Wghtd_2024), reported unchanged. The most-prescribed drug in this group in 2024 was Omeprazole (28.9 million claims). View the full dataset on CMS data.cms.gov.
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Omeprazole
OmeprazoleThis is average Medicare Part D program spending per dosage unit, not a pharmacy cash price or a per-prescription cost. Information only — not medical advice and not a price quote.
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Frequently asked questions
- Which proton pump inhibitors (ppis) are compared here?
- This page compares 2 proton pump inhibitors (ppis) from the CMS Medicare Part D dataset (calendar year 2024): Omeprazole, Pantoprazole Sodium. Each is shown with its real average Medicare Part D spending per dosage unit in US dollars.
- What is the cheapest proton pump inhibitors (ppis) by Medicare spending per unit?
- Among these drugs, Omeprazole had the lowest average Medicare Part D spending per dosage unit at $0.1716 (calendar year 2024), and Pantoprazole Sodium the highest at $0.1987. This is program spending per billing unit, not a retail price, and dosage units differ between drugs.
- Is this the price I would pay for proton pump inhibitors (ppis)?
- No. These figures are average Medicare Part D program spending per dosage unit from CMS open data, not a pharmacy cash price or per-prescription cost. What you pay depends on your pharmacy, insurance, manufacturer, dose and region. This is information only, not medical advice.
- Can a GeraClinic clinician help with acid reflux, GERD and stomach ulcers?
- A GeraClinic clinician can review your medication for acid reflux, GERD and stomach ulcers, explain the options, and issue or renew a prescription online where clinically appropriate. GeraClinic only lists independently verified, licensed clinicians.
Need help with acid reflux, GERD and stomach ulcers?
A GeraClinic clinician can review your medication, explain the options, and issue or renew a prescription online where clinically appropriate — without travelling to a clinic.
Contains public sector information published by U.S. Centers for Medicare & Medicaid Services (CMS) and licensed under the U.S. Government Works / Public Domain. Source: CMS Medicare Part D Spending by Drug (calendar year 2024, published 2026-06-25).
Informational/educational only — not a substitute for professional medical advice; a clinician interprets results.