GLP-1 receptor agonists: Cost Comparison
GLP-1 (glucagon-like peptide-1) receptor agonists are injectable medicines used to lower blood sugar in type 2 diabetes; some are also separately approved for weight management. They are among the highest-cost drugs in the Medicare Part D programme.
Across these 3 drugs, average Medicare Part D spending per dosage unit ranges from $306.48 (Ozempic) to $511.63 (Mounjaro) for calendar year 2024. Figures are real CMS open data, in US dollars.
How much do glp-1 receptor agonists cost in the US?
As of calendar year 2024, average Medicare Part D spending per dosage unit for these 3 glp-1 receptor agonists ranged from $306.48 (Ozempic) to $511.63 (Mounjaro), per CMS open data. These are Medicare program spending figures per billing unit — not pharmacy cash prices, and not medical advice.
| Drug | Generic (active ingredient) | Avg Part D spending / dosage unit | 2024 Part D claims |
|---|---|---|---|
| Ozempic | Semaglutide | $306.48 | 10,417,182 |
| Mounjaro | Tirzepatide | $511.63 | 5,105,397 |
| Trulicity | Dulaglutide | $467.75 | 4,305,141 |
Figures are CMS’s own published Medicare Part D spending values (field Avg_Spnd_Per_Dsg_Unt_Wghtd_2024), reported unchanged. The most-prescribed drug in this group in 2024 was Ozempic (10.4 million claims). View the full dataset on CMS data.cms.gov.
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Ozempic
SemaglutideThis is average Medicare Part D program spending per dosage unit, not a pharmacy cash price or a per-prescription cost. Information only — not medical advice and not a price quote.
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Frequently asked questions
- Which glp-1 receptor agonists are compared here?
- This page compares 3 glp-1 receptor agonists from the CMS Medicare Part D dataset (calendar year 2024): Ozempic, Mounjaro, Trulicity. Each is shown with its real average Medicare Part D spending per dosage unit in US dollars.
- What is the cheapest glp-1 receptor agonist by Medicare spending per unit?
- Among these drugs, Ozempic had the lowest average Medicare Part D spending per dosage unit at $306.48 (calendar year 2024), and Mounjaro the highest at $511.63. This is program spending per billing unit, not a retail price, and dosage units differ between drugs.
- Is this the price I would pay for glp-1 receptor agonists?
- No. These figures are average Medicare Part D program spending per dosage unit from CMS open data, not a pharmacy cash price or per-prescription cost. What you pay depends on your pharmacy, insurance, manufacturer, dose and region. This is information only, not medical advice.
- Can a GeraClinic clinician help with type 2 diabetes (and, separately, weight management)?
- A GeraClinic clinician can review your medication for type 2 diabetes (and, separately, weight management), explain the options, and issue or renew a prescription online where clinically appropriate. GeraClinic only lists independently verified, licensed clinicians.
Need help with type 2 diabetes (and, separately, weight management)?
A GeraClinic clinician can review your medication, explain the options, and issue or renew a prescription online where clinically appropriate — without travelling to a clinic.
Contains public sector information published by U.S. Centers for Medicare & Medicaid Services (CMS) and licensed under the U.S. Government Works / Public Domain. Source: CMS Medicare Part D Spending by Drug (calendar year 2024, published 2026-06-25).
Informational/educational only — not a substitute for professional medical advice; a clinician interprets results.