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Ondansetron HCl Cost — Medicare Part D Spending

Ondansetron HCl (generic Ondansetron HCl) averaged $0.4548 in Medicare Part D spending per dosage unit in calendar year 2024, across 4,180,305 claims — about 4.2 million claims. Figures are real CMS open data, in US dollars.

How much does Ondansetron HCl cost in the US?

As of calendar year 2024, Ondansetron HCl (generic Ondansetron HCl) had an average Medicare Part D spending of $0.4548 per dosage unit, weighted across all manufacturers, over 4,180,305 claims, per CMS open data. This is Medicare program spending per billing unit — not a pharmacy cash price or per-prescription cost, and not medical advice.

Source:CMS Medicare Part D Spending by Drug·as of calendar year 2024updated yearly (last: )
Not medical advice. The figure above is average Medicare Part D program spending per dosage unit, taken unchanged from a public US government dataset for information only. It is not a pharmacy cash price, not a per-prescription cost, and not a price quote. What you pay depends on your pharmacy, insurance, manufacturer, dose and region. Always consult a licensed pharmacist or clinician before making any decision about Ondansetron HCl.
Ondansetron HCl — CMS Medicare Part D Spending by Drug, calendar year 2024 (CMS, public domain)
CMS measureValue
Brand / label nameOndansetron HCl
Generic (active ingredient)Ondansetron HCl
Avg Medicare Part D spending per dosage unit$0.4548
Unitone dosage unit (e.g. tablet, mL, gram)
Total Part D claims (2024)4,180,305
Reference periodcalendar year 2024

Figures are CMS’s own published Medicare Part D spending values, reported here unchanged. The metric is the CMS field Avg_Spnd_Per_Dsg_Unt_Wghtd_2024 — average spending per dosage unit, weighted by claim volume. View the full dataset on CMS data.cms.gov.

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Search any of the highest-volume Medicare Part D drugs by brand or generic name to see its real average spending per dosage unit and 2024 claim volume.

Ondansetron HCl

Ondansetron HCl
Avg Medicare Part D spending
$0.4548 / dosage unit
calendar year 2024
2024 Part D claims
4,180,305
how common it is

This is average Medicare Part D program spending per dosage unit, not a pharmacy cash price or a per-prescription cost. Information only — not medical advice and not a price quote.

Other common Part D drugs

Frequently asked questions

What is the average Medicare Part D cost of Ondansetron HCl?
As of calendar year 2024, Ondansetron HCl (generic Ondansetron HCl) had an average Medicare Part D spending of $0.4548 per dosage unit, weighted by claim volume across all manufacturers, per the CMS "Medicare Part D Spending by Drug" dataset. A dosage unit is one billing unit (e.g. one tablet or millilitre), not a full prescription, and this is Medicare program spending, not a pharmacy cash price.
How common is Ondansetron HCl in Medicare Part D?
Ondansetron HCl had 4,180,305 Medicare Part D claims in 2024 (about 4.2 million claims), placing it among the highest-volume Part D drugs. Claim volume reflects how frequently the drug is dispensed to Medicare Part D beneficiaries, not how much an individual prescription costs.
Is $0.4548 per dosage unit what I would pay at the pharmacy?
No. $0.4548 is the average Medicare Part D program spending per dosage unit in 2024 — not a retail or cash price, and not a per-prescription cost. What you actually pay depends on your pharmacy, insurance plan, manufacturer, dose and region, and on how many dosage units your prescription contains. This figure is for information only and is not a price quote. Check with your pharmacist or insurer for an actual price.
Is this medical advice about Ondansetron HCl?
No. This page presents public US government spending data about Ondansetron HCl for information only. It is not medical advice and not a recommendation to start, stop or change any medication. Always consult a licensed pharmacist or clinician about Ondansetron HCl and your own circumstances.

Need a prescription for Ondansetron HCl?

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Contains public sector information published by U.S. Centers for Medicare & Medicaid Services (CMS) and licensed under the U.S. Government Works / Public Domain. Source: CMS Medicare Part D Spending by Drug (calendar year 2024, published 2026-06-25).

Informational/educational only — not a substitute for professional medical advice; a clinician interprets results.