Cheapest Sertraline HCl Alternatives
Lower-cost options in the same drug family (antidepressants), ranked by average US Medicare Part D spend per dose (calendar year 2024).
What are the cheapest alternatives to Sertraline HCl?
Among antidepressants, the lowest average US Medicare Part D spend per dose is Citalopram HBr at $0.1178 (calendar year 2024, CMS), versus $0.1539 for Sertraline HCl. The full same-class ranking is below. In England the NHS patient charge is a flat £9.90 per item either way. Switching is a clinical decision — information only, not medical advice.
Not medical advice. The figures on this page are drawn unchanged from public government datasets for general information only. They are not price quotes and not a substitute for professional advice. What you actually pay depends on your country, pharmacy, insurance, manufacturer, dose and region. Always consult a licensed pharmacist or clinician before making any decision about Sertraline HCl or switching medication.
The US figure is Medicare Part D PROGRAM spending per dosage unit (in US dollars), not a cash price; the UK figure is the patient's flat NHS charge per item (in pounds). They measure different things in different currencies and are shown side by side, never converted into one another.
| Rank | Drug | US per dose | 2024 US claims |
|---|---|---|---|
| 1 | Citalopram HBr | $0.1178 | 6,741,609 |
| 2 | Trazodone HCl | $0.1467 | 18,424,765 |
| 3 (this drug) | Sertraline HCl | $0.1539 | 16,148,462 |
| 4 | Fluoxetine HCl | $0.1629 | 7,481,805 |
| 5 | Escitalopram Oxalate | $0.1903 | 12,685,003 |
| 6 | Venlafaxine HCl ER | $0.3469 | 5,423,191 |
| 7 | Duloxetine HCl | $0.3506 | 13,094,360 |
| 8 | Bupropion XL | $0.4038 | 6,831,216 |
| 9 | Mirtazapine | $0.464 | 8,338,476 |
Antidepressants span SSRIs (sertraline, escitalopram, fluoxetine, citalopram), SNRIs (duloxetine, venlafaxine) and other agents (bupropion, mirtazapine, trazodone). Most are low-cost generics in Medicare Part D. In England, the NHS patient charge is a flat £9.90 per item for any of these.
See Sertraline HCl on US vs UK
Frequently asked questions
- What is the cheapest alternative to Sertraline HCl?
- By average US Medicare Part D spend per dose, the cheapest antidepressants option is Citalopram HBr at $0.1178 (calendar year 2024), versus $0.1539 for Sertraline HCl. That is a cost figure, not a clinical recommendation.
- Are these alternatives interchangeable with Sertraline HCl?
- Not necessarily. Drugs in one therapeutic class share a broad mechanism but differ in dosing, interactions and suitability. Whether any alternative is right for you is a decision for a licensed pharmacist or clinician.
- Would a cheaper alternative cost less on the NHS in England?
- Not for the patient: England charges a flat £9.90 per NHS item regardless of the drug (and prescriptions are free in Scotland, Wales and Northern Ireland). The per-dose cost gap shown here is a US figure.
Is a lower-cost option right for you?
A GeraClinic clinician can review whether a different antidepressant is appropriate for you, and issue or renew a prescription where clinically appropriate — online.
Contains public sector information published by U.S. Centers for Medicare & Medicaid Services (CMS) and licensed under the U.S. Government Works / Public Domain. Source: CMS Medicare Part D Spending by Drug (calendar year 2024, published 2026-06-25).
Contains public sector information published by NHS Business Services Authority (NHSBSA), NHS England & DHSC and licensed under the Open Government Licence v3.0. Source: NHS prescription charges (England) — NHSBSA / NHS England / DHSC (2026/27 (from 1 April 2026), published 2026-04-01).