Cheapest Metformin HCl Alternatives
Lower-cost options in the same drug family (diabetes medications), ranked by average US Medicare Part D spend per dose (calendar year 2024).
What are the cheapest alternatives to Metformin HCl?
Among diabetes medications, Metformin HCl (generic Metformin HCl) already has the lowest average US Medicare Part D spend per dose ($0.0564, calendar year 2024, CMS). Other drugs in the same family and their per-dose spend are listed below. In England the NHS charge is a flat £9.90 per item whichever you take. Information only — not medical advice.
Not medical advice. The figures on this page are drawn unchanged from public government datasets for general information only. They are not price quotes and not a substitute for professional advice. What you actually pay depends on your country, pharmacy, insurance, manufacturer, dose and region. Always consult a licensed pharmacist or clinician before making any decision about Metformin HCl or switching medication.
The US figure is Medicare Part D PROGRAM spending per dosage unit (in US dollars), not a cash price; the UK figure is the patient's flat NHS charge per item (in pounds). They measure different things in different currencies and are shown side by side, never converted into one another.
| Rank | Drug | US per dose | 2024 US claims |
|---|---|---|---|
| 1 (this drug) | Metformin HCl | $0.0564 | 23,961,097 |
| 2 | Metformin HCl ER | $0.06 | 10,256,666 |
| 3 | Glipizide | $0.0783 | 4,523,542 |
| 4 | Glimepiride | $0.0863 | 4,597,334 |
| 5 | Lantus Solostar | $6.112 | 5,570,732 |
| 6 | Januvia | $17.97 | 4,027,317 |
| 7 | Farxiga | $18.31 | 5,634,650 |
| 8 | Jardiance | $18.94 | 11,368,280 |
| 9 | Ozempic | $306.48 | 10,417,182 |
| 10 | Trulicity | $467.75 | 4,305,141 |
| 11 | Mounjaro | $511.63 | 5,105,397 |
A broad comparison of common diabetes medicines across several classes — metformin, sulfonylureas (glimepiride, glipizide), a DPP-4 inhibitor (sitagliptin), SGLT2 inhibitors, GLP-1 agonists and long-acting insulin — so the cost gap between older and newer therapies is visible side by side. In England, the NHS patient charge is a flat £9.90 per item for any of these.
See Metformin HCl on US vs UK
Frequently asked questions
- What is the cheapest alternative to Metformin HCl?
- Metformin HCl is itself the lowest-cost diabetes medication by average US Medicare Part D spend per dose ($0.0564, calendar year 2024). Other same-class options cost more per dose on that measure.
- Are these alternatives interchangeable with Metformin HCl?
- Not necessarily. Drugs in one therapeutic class share a broad mechanism but differ in dosing, interactions and suitability. Whether any alternative is right for you is a decision for a licensed pharmacist or clinician.
- Would a cheaper alternative cost less on the NHS in England?
- Not for the patient: England charges a flat £9.90 per NHS item regardless of the drug (and prescriptions are free in Scotland, Wales and Northern Ireland). The per-dose cost gap shown here is a US figure.
Is a lower-cost option right for you?
A GeraClinic clinician can review whether a different diabetes medication is appropriate for you, and issue or renew a prescription where clinically appropriate — online.
Contains public sector information published by U.S. Centers for Medicare & Medicaid Services (CMS) and licensed under the U.S. Government Works / Public Domain. Source: CMS Medicare Part D Spending by Drug (calendar year 2024, published 2026-06-25).
Contains public sector information published by NHS Business Services Authority (NHSBSA), NHS England & DHSC and licensed under the Open Government Licence v3.0. Source: NHS prescription charges (England) — NHSBSA / NHS England / DHSC (2026/27 (from 1 April 2026), published 2026-04-01).